產(chǎn)品詳情介紹
白介素-18（Interleukin-18，IL-18），也稱為干擾素-γ誘導(dǎo)因子，是一種促炎細(xì)胞因子，造血細(xì)胞和非造血細(xì)胞等許多細(xì)胞類型都有產(chǎn)生IL-18的潛力[1]。IL-18的主要功能是通過誘導(dǎo)Th1細(xì)胞分泌干擾素-γ （IFN-γ）來實(shí)現(xiàn)的。這種細(xì)胞因子與IL-12協(xié)同作用有助于Th1的分化，在宿主抵御細(xì)胞內(nèi)細(xì)菌、病毒和真菌的防御機(jī)制中非常重要[2]。IL-18與IL-12聯(lián)合使用可激活細(xì)胞毒性T細(xì)胞和自然殺傷細(xì)胞產(chǎn)生IFN-γ，從而可能有助于腫瘤免疫。IL-18的生物學(xué)活性不僅局限于這些細(xì)胞，而且在Th17細(xì)胞反應(yīng)的發(fā)展中也起作用。IL-18與IL-23協(xié)同作用可誘導(dǎo)Th17細(xì)胞分泌IL-17[3]。
[1] Hu B, Ren J, Luo Y, Keith B, Young RM, Scholler J, Zhao Y, June CH. Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18. Cell Rep. 2017, 20(13):3025-3033.
[2] Ihim SA, Abubakar SD, Zian Z, Sasaki T, Saffarioun M, Maleknia S, Azizi G. Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment. Front Immunol. 2022, 13:919973.
[3] Mi J, Liu Z, Pei S, Wu X, Zhao N, Jiang L, Zhang Z, Bai X. Mendelian randomization study for the roles of IL-18 and IL-1 receptor antagonist in the development of inflammatory bowel disease. Int Immunopharmacol. 2022, 110:109020.
