產(chǎn)品詳情介紹
表皮生長(zhǎng)因子（Epidermal Growth Factor, EGF）是一種具有促進(jìn)細(xì)胞增殖和分化作用的多肽，由53個(gè)氨基酸組成，并通過三個(gè)內(nèi)部二硫鍵形成特定的空間結(jié)構(gòu)[1]。EGF與其受體（Epidermal Growth Factor Receptor, EGFR）結(jié)合后，能夠激活受體內(nèi)的酪氨酸激酶活性，這一過程對(duì)于細(xì)胞內(nèi)信號(hào)傳導(dǎo)至關(guān)重要[2]。EGF在多種生物學(xué)過程中發(fā)揮作用，包括細(xì)胞的增殖、分化、遷移和凋亡[3]。重組人表皮生長(zhǎng)因子（rhEGF）的外源性給藥已知可促進(jìn)皮膚傷口愈合，并在藥物輸送系統(tǒng)和納米技術(shù)中越來越廣泛地使用[4] 。
[1] Lu, H., Chai, J., Li, M., Huang, B., He, C., & Bi, R. Crystal Structure of Human Epidermal Growth Factor and Its Dimerization. The Journal of Biological Chemistry. 2001, 276, 34913 - 34917.
[2] Schneider, M., & Wolf, E. The epidermal growth factor receptor ligands at a glance. Journal of Cellular Physiology. 2009, 218.
[3] Bazley, L., Gullick, W. The epidermal growth factor receptor family. Endocrine-related cancer, 2005, 12 Suppl 1, S17-27.
[4] Shin, S., Koh, Y., Lee, W., Seok, J., & Park, K.. The use of epidermal growth factor in dermatological practice. International Wound Journal. 2022, 20, 2414 - 2423.
